Aim and Context: The aim of this study is to investigate the impact of chronic intrauterine hypoxia on cerebrovascular pathology in newborns. This is an important topic because hypoxia (a lack of oxygen) in the womb can have a significant effect on the development of the brain and the central nervous system of the child.

Study of Endothelial Dysfunction Markers: The author conducted research on the levels of endothelin-1 in the blood of newborns. Endothelin-1 is a biologically active substance produced by vascular endothelial cells. Elevated levels of this marker may indicate vascular endothelial damage or dysfunction.

Study of Hemostasis Parameters: Hemostasis is the process of controlling bleeding, and in the article, the author also investigated several hemostatic parameters, including the level of fibrinogen, which is an important factor in the blood clotting process.

Results: The levels of fibrinogen and endothelin-1 were found to be elevated in newborns who experienced chronic intrauterine hypoxia. This may indicate disturbances in the blood clotting system and vascular endothelial function. Elevated levels of endothelin-1 can also affect cerebral hemodynamics, i.e., the blood supply to the brain.

Conclusion: The study highlights the importance of researching cerebrovascular pathology and endothelial dysfunction markers in newborns, especially those who experienced hypoxia before or during childbirth. This helps understand the biochemical changes associated with this pathology and what precautionary measures or treatments can be applied.

Hypoxia, hemostasis, endothelin-1

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