The main function of connective tissues is to provide structural support to other tissues. Cartilage and bone are the main connective tissue types, other types are areolar connective tissue, which holds organs together, and dense connective tissue, which forms ligaments and tendons. We studied 47 pregnant women with uBD and 15 healthy pregnant women without uBD aged 24 to 30 years. 50% of women with uBD were at risk of abortion, and the risk of preterm birth was observed 6 times more often than in healthy pregnant women. Thus, pregnant women with signs of various forms of uBD belong to high-risk groups for obstetric and perinatal pathology and therefore need to be closely monitored during pregnancy, childbirth and the postpartum period. In addition, newborns who have a high probability of inheriting this disease must be examined.

Undifferentiated connective tissue dysplasia (uBD), tumor necrosis factor (TNF-), connective tissue, interleukin-1 (IL-1)

Bukharin O.V., Chepalchenko O.E., Valyshev A.V. et al. Microflora of the large intestine in patients with connective tissue dysplasia. J. Microbiol. Epidemiol. Immunobiol. – 2003- №3. - P.62-66.

Gracheva O.N. Dysplasia connective tissue - prevention of gestational complications. Gin. Akush. and Perinatol. - 2010. - № 3, pp. 25-29.

Golovskoy B.V., Usoltseva L.V., Khovaeva Y.V. et al. Features of the clinical manifestation of connective tissue dysplasia in people of working age. J. Klin. honey. - M. - 2002 - No 80(12) - P.39-41.

Zakharyan A.L., Zakharyan E.L. Severity of varicose veins of lower limbs in various degrees of connective tissue dysplasia. G. wedge. Hir. – 2005. - No8 - P.42 - 44.

Zemtsovskiy E.V. Dysplastic phenotypes [Dysplastic phenotypes]. Dysplastic heart. St. Petersburg: "Olga" - 2007. - P. 68-90.

Kazachkova E.A., Tukay KS. Connective tissue dysplasia syndrome and pregnancy. Moscow, 2007. – 79 p.

Klemenov A.V., Tkacheva O.N., Vertkin A.L. Dysplasia of connective tissue and pregnancy (review). archive. - 2011. - № 11. - P.80-83.

Klemenov A. V. Undifferentiated dysplasia of connective tissue. Moscow, 2005. - 136 p. 129 ZBIRNIK NAUKOVYKH PRATS ASSOCIACII OBSTETRICIAN-GENECOLOGISTS OF UKRAINE Vipusk 1/2 (33/34) 2014 9. Komisarova L.M., Karachaeva A.N., Kesova M.I. Course of pregnancy and childbirth in connective tissue dysplasia. – J. Akush. and gin. - 2012. - No 3 - P.4-7.

Rudnikhina N.K., Vasilyeva A.V., Novikova I.M. et al. Cardiac arrhythmias in pregnant women with connective tissue dysplasia. – J. Akush. and gin. – 2012. - No.3.- P.97-100.

Torshin I.Yu., Gromova O.A. Dysplasia of connective tissue, cellular biology and molecular mechanisms of magnesium impact. – Zh. RMJ. - 2008.- Vol.16, No4. - P.3-11.

Filipenko P.S., Malookaya Y.S. Rol' dysplasia connective tissue v formirovaniya prolapsa mitral'nogo valvea [The role of dysplasia of connective tissue in the formation of mitral valve prolapse]. J. Klin. honey. Moscow, 2006. - No84(12) - P.13-19.

Tsukanov Yu.T., Tsukanov A.Y. Varicose veins of lower limbs as a result of connective tissue dysplasia. J. Angiol. vessel. Hir. -2004 - №10 (2). - P.84 - 89.

Kisters K., Barenbrock M., Louwen F. И соавт. – Membrane intracellular and plasma magnesium and calcium concentrations in preeclampsia // Am. J. Hypеrtens. – 2000. - Vol.13. №7. - Р. 765-769.

Dildora K., Zikiryaevna G., Zarnigor Y. PREGNANCY AND UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA //Central Asian Journal of Medical and Natural Science. – 2023. – Т. 4. – №. 6. – С. 1228-1232.

Khudoyarova D., Shodiklova G., Yunusova Z. RELEVANCE OF THE PROBLEM OF CONNECTIVE TISSUE DYSPLASIA IN OBSTETRICS. – 2024. – T. 3. – №. 1. – P. 13-16.

Adkhamjonovna Q. M., Zarnigor Y. Mathematical Quest as a Learning Activity //Journal of Pedagogical Inventions and Practices. – 2022. – Т. 9. – С. 35-38.

Nuralievna S. N., Maqsadovna Y. Z. Pregnancy and childbirth and complications in women with excess weights & Educational sacrifices. – 2022. – Т. 22. – No. 7. – С. 429-438.

Maqsadovna Y. Z. Pregnant women with morbid obesity: pregnancy and perinatal outcomes //Eurasian Medical Research Periodical. – 2023. – Т. 16. – С. 72-77.

Khudoyarova D., Abdullaeva S. FETOPLACENTAL INSUFFICIENCY WITH HYPOTENSION IN PREGNANT WOMEN // Natural sciences in the modern world: theoretical and practical research. – 2023. – T. 2. – №. 1. – P. 42-47.