Aphthous stomatitis is an urgent problem of modern dentistry and an inflammatory disease of the oral mucosa with a long course. It has been established that recurrent aphthous stomatitis occurs against the background of exacerbation of chronic somatic pathology, which worsens the clinical course and reduces the effectiveness of treatment in these patients. Aphthous stomatitis (AS) is a chronic inflammatory disease of the oral mucosa characterized by the first appearance of aphth in childhood or adolescence, with periodic remissions and frequent exacerbations. According to domestic and foreign authors, aphthous stomatitis affects about 20% of the world's population [1, 2]. Despite numerous studies, the etiology and pathogenesis of the disease have not been fully studied. Provoking factors include immunological and hormonal disorders, genetic predisposition, altered reactivity of the body, sensitization, represented by hypersensitivity to proteinaceous, staphylococcal, streptococcal and E. coli, food allergies, deficiency of vitamins and trace elements, gastrointestinal disorders (celiac disease, Crohn's disease, ulcerative colitis), mechanical damage to the oral mucosa mechanical damage and stress [3-19]. In addition, aphthous stomatitis may be one of the initial manifestations of Behcet's disease [20-25], and it has been established that AS relapses can occur against the background of exacerbation of chronic diseases, worsening the clinical course and reducing the effectiveness of treatment in such patients [26-28]. Therefore, a thorough examination of the patient and consultation with a therapist make it possible to optimize and individualize the approach to the treatment of aphthous stomatitis. The purpose of this study was to study the structure of somatic pathology in patients with aphthous stomatitis.

sensitization, represented by hypersensitivity to proteinaceous, staphylococcal

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