Stress-induced changes in the rectum involve structural and functional alterations affecting its integrity and physiological role. This study examines histological modifications in the rectal wall under immobilization stress, emphasizing epithelial integrity, vascular reactions, and connective tissue remodeling. Morphometric analysis reveals mucosal atrophy, increased inflammatory infiltration, and microcirculatory disturbances. Functional assessments indicate impaired motility and altered mucus secretion, potentially predisposing to chronic pathologies. These findings highlight the significance of stress as a factor in colorectal dysfunction and emphasize the necessity of preventive measures to mi.

Stress, morphofunctional analysis, histological changes

Abdulazizova S. and others . The influence of physical factors on the morphofunctional features of the thymus gland (literature review) //Central Asian Journal of Education and Innovation. – 2023. – Vol. 2. – No. 10. – pp. 5-9.

Abdulkhakimov A. R. et al. Surgical effectiveness of prevention of postoperative purulent complications in children //International Journal of Scientific Trends. – 2025. – Vol. 4. – No. 1. – pp. 155-158.

Averina O. V., Danilenko V. N. Human intestinal microbiota: its role in the formation and functioning of the nervous system //Microbiology. – 2017. – Vol. 86. – No. 1. – pp. 5-24.

Aleksanin S. S. et al. NM, Korsakova NOT, Ponomarenko VM, Poyarkova NA, Tikhomirova OV, Trofimova IV, Frolova MU, Chinenova LV, Shantyr II, Ellinidi VN, Yakovleva MV.

Alekseeva I. V., Abramova A. Yu., Pertsov S. S. Nociceptive sensitivity under stress conditions //The Russian Journal of Pain. – 2022. – Vol. 20. – No. 3. – p. 42.

Andreeva I. V. and others. Psychobiotics: a new direction in psychopharmacology, or how do bacteria affect our brain? //Clinical microbiology and antimicrobial chemotherapy. – 2022. – Vol. 24. – No. 2. – pp. 108-133.

Ardatskaya M. D. et al. Intestinal dysbiosis: current state of the problem, comprehensive diagnosis and therapeutic correction //Experimental and clinical gastroenterology. – 2015. – №. 5 (117). – Pp. 13-50.

Ardatskaya M. D., Loginov V. A., Minushkin O. N. New possibilities for the diagnosis and correction of intestinal microecological disorders //Consilium medicum. Gastroenterology. 2013. Vol. 2. pp. 51-58.

Akhmedov V. A., Orlov I. N., Gaus O. V. Modern methods of rehabilitation of patients with irritable bowel syndrome //Therapy. - 2017. – No. 3. – pp. 49-55.

Bagmut I. Y. Structural and metabolic disorders and their mechanisms under the influence of oligoesters on the body and pathogenetic substantiation of the principles of their early diagnosis and correction : Kharkiv Medical Academy of Postgraduate Education, 2015.

Balukova E. V. New possibilities of pathogenetic therapy of irritable bowel syndrome // Breast cancer. – 2015. – T. 23. – No. 21. – pp. 1253-1257.

Batyrova A. N. et al. Erosive and ulcerative lesions of the gastroduodenal zone in stressful situations (operations, trauma and shock) and severe diseases of internal organs (literature review) //Bulletin of the Kazakh National Medical University. 2014. No. 1. pp. 9-11.

Belokoskova S. G., Tsikunov S. G. Vasopressin in the mechanisms of stress reactions and emotion modulation //Reviews on clinical pharmacology and drug therapy. – 2018. – Vol. 16. – No. 3. – pp. 5-12.

Bobyntsev I. I., Medvedeva O. A. Dynamics of the state of the nervous system functions, microbiota and morphofunctional parameters of the colon when using the N-terminal analog of ACTH in conditions of chronic immobilization stress.

Bobyntsev I. I., Medvedeva O. A. Dynamics of the state of the nervous system functions, microbiota and morphofunctional parameters of the colon when using the N-terminal analog of ACTH in conditions of chronic immobilization stress.

Bodrov V. Psychological stress: development and overcoming. – Litres, 2015.

Bronskaya I. D. Theoretical review of stress psychology //Psychology. Historical and critical reviews and modern research. – p. 353.

Vatazin A.V. et al. Pathogenetic mechanisms of development of ischemic and reperfusion injury of the kidney as promising targets of specific therapy //Bulletin of Transplantology and Artificial Organs, 2015, vol. 17, No. 1, pp. 147-156.

Ganizhonov P. Kh. and others. Stress and its effect on the state of the mucous membrane of the digestive tract: morphological and functional changes (literature review) //Consilium Medicum. – 2024. – Vol. 26. – No. 5. – pp. 286-291.

Ganizhonov P. Kh. et al. Stress and its effect on the state of the mucous membrane of the digestive tract: morphological and functional changes (literature review) //Consilium Medicum, 2024, vol. 26, No. 5, pp. 286-291.

Ganizhonov P. H., Mirzazhonova S. A. The effect of stress on the physiology and morphology of the digestive system: aspects of changes (literature review) //Economics and society. – 2023. – №. 12 (115)-2. – Pp. 738-750.

Hypoxia And. Experimental articles //Russian Journal of Physiology Named after Named after Sechenov. – 2021. – Vol. 107. – No. 11. – pp. 1385-1394.

Gorobets T. N., Zhdanov O. I. Stress: essence, function, meaning //The world of psychology. - 2008. – No. 4. – pp. 45-54.

Grinevich V. B. and others. Lesions of the digestive system in postcovoid syndrome. Clinical recommendations //Experimental and clinical gastroenterology. – 2022. – №. 12 (208). – Pp. 4-68.

Gubergrits N. B. et al. Chronic constipation.

Gudkov A.V., Selivanov F. O. The latest antiviral agents used to treat hepatitis C //Integration of theory and practice in medicine: achievements of I. – S. 91.

Gutsol L. O. et al. Stress (general adaptation syndrome) //Baikal Medical Journal, 2022, vol. 1, No. 1, pp. 70-80.

Dargaeva T. D. Theoretical and experimental substantiation of the development and standardization of herbal remedies recommended for the treatment and prevention of diseases of the digestive system. – 2012.

Dorofeev A. E., Rassokhina O. A., Kovalenko-Ratushnyak S. V. Irritable bowel syndrome -a modern view of the problem //Medical and pharmacy news. – 2011. – No. 1. – pp. 10-21.

Drozdov V. N. et al. The place of antispasmodics in the treatment of irritable bowel syndrome //Medical Council. – 2021. – №. 5. – Pp. 155-164.

Evseev M. A., Fomin V. S., Nikitin V. E. Pathogenetic aspects of the development of enteral insufficiency syndrome in the postoperative period //Annals of surgery. – 2018. – Vol. 23. – No. 1. – pp. 5-13.

Zhdanova O. B. Helminthiasis of laboratory animals and nutria. Their diagnosis and prevention.

Zakharova I. N. et al. Stress and stress-induced disorders in children //Medical Council. – 2018. – №. 11. – Pp. 110-116.

Zakharova I. N. et al. Stress in children and adolescents is a problem today //Medical advice. – 2021. – №. 1. – Pp. 218-227.

Ziruk I. V., Salautin V. V., Kopchekchi M. E. The effect of a complex of trace elements based on l-aspartic acid on the morphofunctional parameters of piglets. – 2022.

Zolotoe E. V. et al. The effect of stress on the human body //Bulletin of the ambulance service. – 2022. – Vol. 3. – No. 1. – pp. 10-18.

Ivanov A. N., Pucinyan D. M., Norkin I. A. Barrier function of the endothelium, mechanisms of its regulation and disorders //Successes of physiological sciences. 2015. Vol. 46. no. 2. pp. 72-96.

Kagan I. I., Chemezov S. V. Topographic anatomy and operative surgery //Moscow: GEOTAR-Media– 2009.-672 p. – 2011.

Kolmakova T. S. Changes in the morphological composition of blood, metabolic parameters and ways to correct them under stress in service dogs.

Kolmakova T. S. Changes in the morphological composition of blood, metabolic parameters and ways to correct them under stress in service dogs.

Kurygin A. A., Scriabin O. N. Acute postoperative gastroduodenal ulcers. – 1996.

Lapina T. L., Kartavenko I. M. Ursodeoxycholic acid: effect on the mucous membrane of the upper gastrointestinal tract //Russian Journal of Gastroenterology, Hepatology, and Coloproctology. - 2007. – Vol. 6. – pp. 41-50.

Lendov A. O. Study of the effect of alpha-tocopherol on morphometric parameters of the thyroid gland //The Editorial board. 2016. pp. 52-45.

Luft V. M., Kostyuchenko A. L. Clinical nutrition in intensive medicine. – 2002.

Mazur I. A. et al. Reviewers: Professor Gudivok YAS, Professor Voitenko NG.

Malkoch A.V. and others. The development of anemia in certain diseases of the gastrointestinal tract in children //Attending physician. – 2010. – №. 1. – Pp. 27-27.

Mizin V. I. et al. Functional effectiveness of biologically active substances of grapes (scientific review) //Current issues of physiotherapy, balneology and medical rehabilitation. 2015. pp. 1-58.

Morozov V. N., Khadartsev A. A. Towards a modern interpretation of stress mechanisms //Bulletin of New Medical Technologies. – 2010. – Vol. 17. – No. 1. – pp. 15-17.

Nasyrova R. F. et al. An algorithm for diagnosing a chronic inflammatory reaction in schizophrenia //Diagnosis and treatment of mental and drug-related disorders: modern approaches. - 2024. – p. 78.

Nikolaev Yu. A. Russian Academy of Medical Sciences Siberian Branch of the Federal State Budgetary Institution "Federal Research Center for Fundamental and Translational Medicine".

Nishanov Yu. N. and others. Features of blood supply to the wall of the small intestine and its Peyer's patches //Experimental and clinical gastroenterology. – 2020. – №. 3 (175). – Pp. 66-70.

Oreshko L. S., Solovyova E. A. Anemic manifestations in malabsorption syndrome and their correction //Gastroenterology of St. Petersburg. - 2016. – № 1-2. – pp. 2-5.

Pakhomova I. G., Belousova L. N. Irritable bowel syndrome. New possibilities of pharmacotherapy //Russian Medical Journal. Medical review. - 2014. – Vol. 22. – No. 31. – pp. 2222-2226.

Pashchenko P. S., Gaivoronsky I. V. History and prospects of development of domestic morphological studies of the effects of gravitational overloads on the body in experiment //Vestn. Ross. military.-med. akad.-2015.-4 (52).-p. 2015. – Vol. 236. – p. 245.

Ordin G. V. and others. Pathogenetic mechanisms of the relationship between osteoarthritis and intestinal dysbiosis //Archive of Internal Medicine. – 2023. – Vol. 13. – No. 5. – pp. 325-334.

Pushkina T. A. Improving the physical performance of highly qualified athletes based on the use of a complex antioxidant product.

Ryzhevol E. V. and others. Psychophysiological mechanisms of tension and stress (review of Russian sources, 20052021) //Bulletin of Psychophysiology. - 2021. – No. 4. – pp. 19-36.

Samsonov A. A., Andreev D. N., Dicheva D. T. Irritable bowel syndrome from the perspective of modern gastroenterology //Pharmateca. – 2014. – Vol. 18. – No. 291. – pp. 7-14.

Sevostyanova O. I. Development and clinical and therapeutic justification of the use of vitamin and mineral complex in poultry farming : Dissertation for the degree of Candidate of Biological Sciences. Stavropol, 2016.

Semenova N. V. et al. Organization of medical care for people with post-traumatic stress disorder: methodological recommendations. – 2022.

Smirnova A.V., Koryagina O. A. Stress and the physiological response of the body. Exam stress among students //International Student Scientific Bulletin.-2019.–№. – 2019.

Smirnova V. O. The possibility of correcting the components of the metabolic syndrome with a melatonin preparation." //Volgograd State Medical University" of the Ministry of Health of the Russian Federation. – 2018.

Tolmacheva N. V., Suslikov V. L. Investigation of the risk of atherosclerosis in experimental modeling //The successes of modern natural science. – 2007. – №. 12. Pp. 45-46.

Fattakhov N. H., Abdulkhakimov A. R. Unique features of the auricle structure //Re-health journal. – 2022. – №. 4 (16). – Pp. 17-19.

Fedotchev A. I. Stress, its consequences for humans and modern non-medicinal approaches to their elimination //Successes of physiological sciences. – 2009. – Vol. 40. – No. 1. – pp. 77-91.

Khadartsev A. A. et al. Depression of anti-stress mechanisms as the basis for the development of the pathological process //Fundamental research. - 2012. – No. 4-2. – pp. 371-375.

Khadartsev A. A. and others. The pathophysiology of stress as a balance of stress-causing and anti-stress mechanisms //Bulletin of Neurology, Psychiatry and Neurosurgery. – 2012. – No. 7. – pp. 016-021.

Khomidchonova Sh. Kh., Abdulkhakimov A. R. Morphofunctional aspects of the effect of stress on the tissues of the rectum in rats //yangi o'zbekiston, yangi tadqiqotlar jurnali. – 2023. – Vol. 1. – No. 1. – pp. 156-157.

Khomidchonova Sh. Kh., Abdulkhakimov A. R. Morphofunctional features of rectal tissues in rats under stress //yangi o'zbekiston, yangi tadqiqotlar jurnali. – 2023. – Vol. 1. – No. 1. – pp. 158-159.

Zimmerman Ya. S. Irritable bowel syndrome: what is its true essence? //Clinical medicine. 2014. Vol. 92. no. 7. pp. 19-29.

Shabanov P. D., Lebedev A. A. Hormonal mechanisms of dependence. The concept of hypercirculation in the amygdala-hypothalamic-pituitary-adrenal system //Human ecology. - 2009. – No. 8. – pp. 19-24.