The work environment plays a pivotal role in shaping the productivity and outcomes of research and commercialization activities, particularly in innovation-driven sectors. This study explores the impact of various work environment factors—such as organizational culture, physical space, collaboration, and leadership—on research output and the commercialization of new technologies and products. By analyzing data from universities, research institutes, and private companies, the research examines how these factors influence not only the quality of research but also its potential to be commercialized successfully. The findings suggest that a conducive work environment, marked by open communication, cross-disciplinary collaboration, and supportive leadership, significantly enhances both the efficiency of research and the success rate of commercialization efforts. The paper concludes by offering recommendations for organizations looking to foster an environment that enhances research productivity and commercialization outcomes.